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Hey Viagra users! Do you know how your magic pill works on you? Hmmm…forgotten right! Or are you ignorant about its mechanism? Whatever, am sure about one thing you were startled after reading the title of this write-up! To understand Viagra mechanism we need to first understand how one gets a penis erection. Penile erection process is initiated with sexual excitement. The stimulation generates electrical impulses in the brain and sends it to the nerves going to the penile section. The nerve then releases nitric oxide to increase the production of cyclic GMP in muscle cells of corpus cavernosum simultaneously. Nitric oxide smoothes the muscles and increases the size of the blood vessels allowing high-speed blood flow to the penis. As a result the penis is engorged with blood making it firm and strong for penetrative sex. So what we understand from this is that the level of NO (Nitric oxide) is mainly responsible for giving a strong penile erection. Viagra does not have any direct relaxant effect on the penile section but it enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5). When sexual stimulation leads to the release of Nitric oxide, the inhibition of PDE5 by Viagra causes increased levels of cyclic guanosine monophosphate which gives muscle relaxation and blood inflow to the corpus cavernosum which ultimately helps in getting the required erections of the penis. Now, I am sure you will be able to relate the Nobel Prize winner Dr. Furchgott with Viagra and its functioning. Nitric oxide was initially known as Endothelial Derived Relaxing Factor (EDRF), ERDF was released, when patients took the nitrate-type blood pressure medicines popular in the 1970s and 1980s, and in turn it caused relaxation of the smooth muscles around the blood vessels and the arteries became larger, allowing better blood flow and a lower blood pressure. In 1986, Dr. Furchgott identified the EDRF as nitric oxide. This is where the Viagra makers got the idea of a magic pill for sex which revolutionized the whole idea of impotence. They noticed from the research that the nitrate drugs had certain side-effects on the blood vessels and the arteries; relaxing the smooth muscles around the blood vessels thereby increasing the blood flows in the human body. They related it to the erectile anatomy and discovered Sildenafil citrate, a chemical that inhibited PDE5 inhibitors which is responsible for the level of NO (nitric oxide) in the penile section. Sildenafil Citrate, under the brand name of Viagra, became the pioneer pill for the treatment of erectile dysfunction and received FDA approval on March 27, 1998, the rest is history! After all a better blood flow is the key factor behind a strong erection. So the master mind behind Viagra, in a way, remains Dr. Furchgott, the inventor of nitric oxide. Without the knowledge of the existence of nitric oxide, no one could think of inhibiting phosphodiesterase type 5 to maintain the level of NO to get penis erection. Let’s toast for the good health of Dr. Furchgott and congratulate him on winning the Nobel Prize. Without his discoveries Viagra would not have been possible and millions of men with erectile dysfunction would have continued to live hopelessly and helplessly as ‘ashamed impotents’. Thanks Dr. Furchgott for everything you have given us through your discovery! penis enargement excercises vigrx for men herbal natural penis enargement free penis enhancement video magna rx pill natural penis enlarement technique penis enlargment exercise cheapest penis enlagement pills

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The Prostate: Part I – BNP What is situated below a body of water, has four zones and is commonly associated with venial pleasures. No it is not some romantic European city, but rather a walnut sized male organ that serves important procreative functions. It also happens to be an organ that plagues men as we age. This organ or gland is the prostate. This is the first of two articles on the male prostate. This article will focus on a disease process that affects older men, something we refer to as benign prostatic hyperplasia (BPH). BPH is a non-cancerous growth in the size of the prostate gland that impairs the flow of urine out of the bladder. The second article will focus of prostate cancer. But first a little about the small yet important male organ. The gland is located just below the bladder. It usually measures one inch by one-and-a-half inches (approximately the size of a walnut). It surrounds the urethra (the tube that takes urine out of the bladder). It is responsible for producing a fluid important in male sexual function. In the past the prostate was described as having “lobes”, but today we refer to it as having concentric zones. These zones are important both on an anatomical as well as histological level. We can separate pathology along these zones as well. For instance most all cancers occur in the peripheral zone while the benign process of enlargement occurs almost exclusively in the transitional zone (which only occupies about 5% of the total prostate volume). The prostate gland is also made up of different cell types. Cancer cells develop from the epithelial cells, but it is the interaction with stromal cells that is important in the behavior of the cancer. BPH develops from an interaction between these cells as well, but it is complex and poorly understood. Testosterone and other hormones and their interactions with this gland are hot topics of research in understanding prostate disease. The prostate gland produces most of what is found in the male ejaculate. The average volume is about 3 mL. This is less than a teaspoon and only 1% of it is sperm. The majority of the semen volume is made of products of the seminal vesicles and the prostate. The male ejaculate is very rich in potassium, zinc, citric acid and fructose. Along with these substances it also contains prostaglandins. There are many other unusual substances found in the semen. Not all is know about their function or purpose. This important male organ is a complex mix of anatomical structures and cell types that make it possible for human reproduction. However beyond the reproductive years of men, this organ becomes one of burden rather than usefulness. We will discuss the finer points of BPH and how to best avoid it and if plagued with it, treatment options. BPH typically affects men from their fourth to fifth decade of life and beyond. Several hormones come into play that have a drastic effect on the transitional zone (the zone that is most central and surrounding the urethra). Namely a metabolite of the male androgen Testosterone called Dihydrotestosterone (DHT) plays a big part on the enlargement of cells of the prostate and the encroachment on the urethra. There are several signs and symptoms that correlate with BPH and they are: slow urinary flow, the urge to urinate all the time, nighttime urination, enlargement and distension of the bladder with continuous urine leakage (incontinence) and urinary obstruction. Autopsies suggest that more than 90% of men older than 70 years have BPH. The average age for symptomatic development is about 65 years for white Americans and about 60 years for African-American men. Ways to prevent the effects of DHT on the prostate gland and the ensuing enlargement are via medications that block the enzyme 5-alpha-reductase, which converts Testosterone to DHT. Proscar is such a drug commercially available through a pharmaceutical company. Proscar works on blocking the effects of androgens on the epithelial cells and can actually shrink the size of the prostate making some of the symptoms of BPH resolve. Alternatively two FDA approved drugs that aid in symptoms of BPH (but act differently than Proscar) are Hytrin and Cardura. Both Hytrin and Cardura are drugs in the alpha1-blocker class. Originally researched as a centrally acting blood pressure reducer for patient with hypertension, it was discovered that this drug would actually relax the prostate tissue surrounding the urethra making symptoms of BPH resolve. Side effects generally include low blood pressure, dizziness, and nasal stuffiness. While neither of these two drugs will “cure” or reverse the process, they certainly do provide symptom relief for the patient plagued with BPH. Another way to treat this disease and a more natural approach is the use of herbs know for their anti-androgenic effects on the prostate. These include the well-studied Saw Palmetto herbal extract that blocks 5-alpha-reductase in the same manner as the prescription drug. Saw Palmetto taken in a standardized dose of 160mg twice daily has shown increased urine flow, with minimal side effects. Saw Palmetto is an herb indigenous to the Lowcountry of Georgia and South Carolina. Pygeum Africanum is shown to do the same yet it is not as effective and there is a fair degree of stomach symptoms. Pygeum is derived from an African evergreen tree. Stinging Nettles (Radix urticae) is another herb used widely in Europe for prostate health that has been shown to lower the residual urine volume in men with enlarged prostates. These phytotherapeutics (plant derived medicines), used and described by the Egyptians as far back as the 15 Century B.C., have a common compounds called phytosterols. The most effective phytosterol is beta sito sterol for BPH. None of the medications or herbs has been shown to prevent prostate cancer. These prescription medications and herbs are for the treatment, reduction in size or prevention of the benign process of enlargement of the prostate. Prostate cancer prevention and treatment is by other means and the subject of the next article. Besides the herbal and drug therapies there are a few surgical therapies worth mentioning. These include the most common transurethral resection of the prostate or TURP. This is where under the care of an urologist the constricted urethra within the prostate gland is “reamed out” thus mechanically or surgically widened the opening. A variant of this is the transurethral incision of the prostate (TUIP) where an incision rather than resection of the tissue is performed. A suitable procedure for patients with prostates 100 mL in volume. This involves an abdominal operation and removal of the whole prostate. Of course symptoms mentioned above for TURP are of greater frequency with this more radical procedure. There is also thermotherapy (a type of microwave treatment) that alleviates irritative symptoms, but not much is available in long-term results in the medical literature. And finally stent placement is an option. This can be used in selected cases of patients with a poor general condition and in the non-operative candidate. Symptoms of BPH include: Obstructive symptoms: Hesitancy in initiating voiding (trouble getting started) Weak urinary stream, prolonged voiding Post-voiding dribbling (mild incontinence) Sensation of incomplete emptying Nocturia (night time urination) Overflow incontinence Acute urinary retention (very painful condition) Irritative symptoms: Dysuria (discomfort in urination) Frequency Urgency Scoring BPH: The American Urological Association Symptom Index (AUASI) and International Prostate Symptom Score (IPSS) are now considered the gold standard measurement tools for the assessment of BPH symptoms and response to treatment. Both questionnaires can be used by a physician in a clinical practice to quantify the subjective symptoms of BPH and monitor therapies. Part II in this series will cover annual examination of the prostate, blood testing, prostate cancer. It will also cover prevention and treatment of prostate cancer. Reference: http://www.prostatehealth.com Lowe, FC. Et al, Phytotherapy in treatment of benign prostatic hyperplasia: a critical review. Urology 48:12-19, 1996 Dreikorn, K. et al, Stellenwert von Phytotherapeutica dei der Behandulng der benighnen Prostatahyperplasia. Urologe (A)34:119-129, 1995 Fitzpatrick, J.M. et al, Phytotherapeutic Agents in Management of Symptomatic Benign Prostatic Hyperplasia. Urological Clinics of North America. 22:407-412, 1995 Wilt T, Ishani A, Mac Donald R.. Serenoa repens for benign prostatic hyperplasia. The Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD001423. DOI: 10.1002/14651858.CD001423. [Research by Sagalowski and Wilson, 1998] © 2005 result review vigrx penile enlargment surgery photo enlargement manhattan penile vimax does penis enlargement work natural penis enargement exercise free penis enlarement technique penis enlargment picture pennis enlargement pic vimax penis enlargement before and after picture

A fiery debate has long raged in the medical profession on whether male menopause actually exists and what, if any, is its effect on male sexual performance. The questions are many. If it really does exist, at what age will it begin to affect their sexual performance? What precautions can be taken to avoid its arrival and are there treatments to help reverse it? If it's real, how does it differ from female menopause? It's a no-brainer that men go through sexuality changes as they age, just as women do. The erection-on-demand performance they enjoyed as teens is no longer the case at age forty. Little by little as they age, men begin to notice changes in their sexual performance as the urge for sex also lessens. As they age, it takes longer for men to get an erection to come on and the penis requires more direct stimulation to get and stay aroused. The erection may also be angled, rather than straight and rigid and ejaculation may not be as forceful. Also, the time it takes between erections gets longer. Rather than physical, the decrease in a man's sexual performance could also be due to psychological factors like a mid-life crisis. His waning sexual performance could be blamed on any number of external factors. It could be due to lack of interest in an aging wife who isn't the babe she was ten years ago, the stress of work, demands of growing children, or financial difficulties, even worries about caring for aging parents. So how do you differentiate between a mid-life crisis and male menopause? A mid-life crisis is more a problem of psycho-social adjustment, meaning it may have nothing to do with a man's sex life. However, male menopause is distinctly physiological in nature, similar in many ways to female menopause. Because frequently men can have both physical and psychological factors affecting them, the line between male menopause and mid-life crisis becomes hazy. Although menopause is most often associated with women, men experience a different type of menopause or 'life change.' Where women cease to menstruate and usually can no longer get pregnant, men can continue to father children. Symptoms of menopause in both men and women are similar and can sometimes be just as overwhelming. As reported in Andrology: The Science of Dysfunctions of the Male Reproductive System, approximately 40% of men between 40 and 60 will experience some degree of lethargy, depression, irritability, mood swings, hot flashes, insomnia, decreased sex drive, weakness, loss of both lean body mass and bone mass, making them susceptible to hip fractures, and difficulty in attaining and sustaining erections (impotence). Testosterone (male sex hormone) stimulates sexual development in male infants, bone and muscle growth in adult males and also controls sex drive and male sexual performance. The levels of testosterone diminish gradually after age 40. In healthy males age 55, the amount of testosterone is significantly lower than 10 years earlier, and by 80 decreases to pre-puberty levels. In 1944 what is now described as male menopause was reported in a key article written by two American doctors, Carl Heller and Gordon Myers. Comparing symptoms with that of female menopause, they did a blind controlled trial showing the effectiveness of testosterone treatment. But like many pioneering efforts their findings were vastly unreported due to men being unwilling to accept that they could have 'menopause,' while men with genuine symptoms and sexual dysfunctions were often told it was a mid-life crisis or just in their heads. Around the same time testosterone therapy had come into disrepute in the public eye due to athletes misuse and abuse. So the concept of male hormone replacement therapy for male menopause symptoms, impotence, or sexual performance problems wasn't very well received. Added to that, the hype about side effects and the tie between prostate cancer and hormone replacement further negated its acceptance by many men. Only after HRT (Hormone Replacement Therapy) became popular and produced desirable results for women, providing tangible improvement in symptoms and 'age reversal' in post-menopausal women, did men begin to take notice and jump on the bandwagon, not wanting to get left behind their female counterparts. penis elargement excersizes home penis enargement manual penis enlargement penis enargement result vimax penis enlargement before and after penis enlargement excercises free penis elargement natural penis elargement exercise vimax penis enlargement before and after picture

Men's health supplements can target issues specific to males as well as promote general health and well-being. As such, more and more men are looking into vitamins, minerals, herbs and other natural supplements to improve their health. Two of the main concerns for men as they get older are prostate health and impotence or low libido. Although there are prescription medications that can help with both of these issues, the problem is there are some serious side effects to contend with, as there are with all pharmaceutical drugs. Fortunately, there are natural alternatives that can be just as effective without the potential complications, which is why they can be a better, safer option for the male population. There are a number of male dietary supplements that can be beneficial to prostate health, either on their own or in combination with other nutrients. Saw palmetto, an herb native to the Atlantic seaboard, is one of the most popular and extensively researched mens health supplements. It contains a compound called beta sitosterol, which interferes with the conversion of testosterone to DHT, the main cause of prostate enlargement. Studies show that saw palmetto can actually shrink prostates as well as relieve urinary problems. Another of the top rated mens dietary supplements is red clover, a member of the pea family that also inhibits DHT as well as fights off cancerous growths. Some of the other important mens health nutrients are zinc, which prevents infection in the gland, vitamin B6, which regulates the hormones that manufacture DHT, and lycopene, which can reduce inflammation and fight off prostate cancer. Impotence or low male libido is another issue that can be helped with mens health supplements. This is a problem that affects millions of men each year, and can be caused by a number of factors from stress to depression to alcoholism. The male dietary supplements that treat this issue basically work in one of three ways: relaxing the mind, promoting circulation or balancing sex hormones. Some of the top rated mens dietary supplements for impotence include ginkgo biloba, which can increase circulation to the male organ as well as stimulate the mind and concentration; gotu kola, which serves a similar function; muira puama, which can increase libido and balance hormone levels; and tribulus, which can help with impotence and infertility as well as stimulate hormone production. L-Arginine is an essential amino acid which can also fight low male libido. So as you can see, there are a number of mens health supplements that can help promote prostate health and prevent or treat low libido or impotence, two of the leading male health concerns. Most of the top rated mens dietary supplements are available online, but make sure you consult a health professional first before you begin supplementation. He or she will help you find the male dietary supplements that are right for you. penile enlargment before and after picture penis enargement surgery picture cheapest penis enlarement pills penile enlargment technique male penis enargement top penile enlargement pills surgical pennis enlargement penis enhancement information vimax penis enlargement before and after picture

Manufacturers claim the pumps are a miracle treatment for women who dream of fuller and supple breasts without the pains and health problems associated with surgery. Breast enlargement pumps consist of a pump attached to a specially designed cups or cylinders. Each cup or the cylinder is attached to the breasts and manually pumped up to a good pressure. This procedure is repeated for 15 minutes twice a day to produce the best results. According to the manufacturer, the external pressure creates a suction by which the breasts are pulled outward. This process increases vacuums of fat and fluids and makes them flow into the breast tissue cells causing them to enlarge. Pumps also helps to build and expand the mammary gland tissue by stimulating a balanced natural hormone level and encourages increased production of collagen to provide firmer breasts. Some manufacturers claim that regular stimulation of the breast tissue by pumps induces the pituitary gland to increase the production and release of the female hormones responsible for breast growth. Besides, regular stimulation and the gentle stretching of the breast repeatedly induces new cellular growth and enlarges the breast. The process works in the same manner as regular exercising does for muscle growth. Whether the breast enlargement pump is effective in the enhancement of the breasts is still a matter of speculation. Many doctors deny any role of pumps in the process of breast enlargement. The supposed increase in the size, doctors say, is purely a placebo effect. Secondly, the elastic nature of the skin responds to the prolonged pumping by stretching itself to an extent as to give the effect of an enlargement. Some women claim that prolonged use of pumps has increased their breast by 2 cups. Some have reported an increase by a cup size within three weeks. The use of breast enlargement pumps may harm or damage the breast tissue, so before deciding on the use of pumps it would be worth the effort to investigate all information thoroughly.